3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway

Traditional Chinese medicine (TCM) has been increasingly employed in the last decades China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient TCM “Chanpi” with anti-tumor potential. However, effect mechanism on colorectal cancers were not well disclosed. The present study demonstrated that could reduce viability, trigger apoptosis, block cell cycle at G2/M stage cancer lines HT29, RKO, COLO205 vitro. Moreover, inhibited JAK1/STAT3 signaling pathway. These results indicated anti-proliferation ability cells.